Acetaminophen :: essays research papers

acetaminophenIn the late 1800s it was disc all all overed that papa-amino-phenol, could reduce fever, entirely the dose was too toxic to use. A less toxic extract called phenacetin was later found to be just as effective but overly had pain-relieving properties. In 1949, it was learned that phenacetin was metabolized into an active but also less toxic drug, acetaminophen. Since then, acetaminophen has been sold under many over the counter brand names, most popular being Tylenol.Acetaminophen serves atomic number 53 basic purpose, to shut up pain. It is the main ingredient in pain killers that relieve headaches. It also substitutes anesthesia in circumcision surgery be engender anesthesia often dropnot be used on babys. Dr. Michael Weitzman and 2 new(prenominal) doctors performed an experiment on an infant to test the effectiveness of the drug. The results were not identical, but there were increases in boldness rate respiratory rate and crying. But the drug did more grea t as a pain reliever after the surgery than originally the surgery. Acetaminophen is ingested orally and is rapidly and completely absorbed into the gastrointestinal tract. It work in about one hour. The liver detoxifies 90% of it by flux it with sulfuric acid, and another 3-5% is catabolized by enzyme reactions to the acid. The metabolites are excreted in the urine. The dosage of the drug should be used according to the carton instructions. A 10 gigabyte over dose in adults, 140 mg for kids, can cause permanent liver damage. Also if you had just taken some other drugs , The acetaminophen may become more toxic since the drugs are catabolized in the liver. To protect yourself from injury, you should take 1 gram of vitamin C and Cysteine -a bodily antioxidant.The kidneys can be permanently damaged if you continuously take the drug over a long period of time. You can get all kinds of cancers such as heart, liver , kidney. 40 % increase There are no nutrient supplements known to p rotect against kidney damage, but some amino acids such as Taurine powder and lots of Vitamin E might help. many people alternate the use of other OTC such as Aspirin, which also has other dangerous effects , but hopefully pass on reduce acetaminophen toxicity.